THE PROBIO TRIAL: MOLECULAR BIOMARKERS FOR ADVANCING PERSONALIZED TREATMENT DECISION IN PATIENTS WITH METASTATIC CASTRATION-RESISTANT PROSTATE CANCER

Abstract Background Multiple therapies exist for patients with metastatic castration-resistant prostate cancer (mCRPC).However, their improvement on progression-free survival (PFS) remains modest, potentially explained by tumor molecular heterogeneity.Several prognostic molecular biomarkers have been identified for mCRPC that may have predictive po

The diets and environments that individuals experience can vary greatly within and among wildlife populations.These individual experiences can be compared using the chemical signatures of animal tissues, which can differentiate animals into groups, including those raised in the wild versus those held in captive facilities.In this study, we compared

STAT3 activation is frequently detected in breast cancer and this pathway has emerged as an attractive molecular target for cancer treatment.Recent experimental evidence suggests ALDH-positive (ALDH(+)), or cell surface molecule CD44-positive (CD44(+)) Potty but CD24-negative (CD24(-)) breast cancer cells have cancer stem cell properties.However, t

In this paper, we analyze whether work values differ between three dimensions of time (age, birth cohort, period).Using data of five waves of the World Values Survey and the European Values Study from more than forty countries and hierarchical age-period-cohort regression models, we did not find relevant gaps between birth cohorts with respect to t